Induction of Ovarian Tumours with 9:10-Dimethyl-1 : 2-Benzanthracene

Emulsions Containing 9,1O-Dimethyl-1, 2-Benzanthracene

Emulsions of fat suitable for intravenous ad ministration have been used in this laboratory as @ source of calories, as an aid in the study of lipid metabolism, and as a vehicle for fat-soluble ma tenials. The latter use has been of value in studies with rats on the effects of the intravenous injection Cof carcinogenic hydrocarbons. Several investiga tions have been reported in which emulsions ...

Metabolic and carcinogenic studies with 9, 10-dimethyl-1, 2-benzanthracene.

Induction of skin tumors in the mouse with minute doses of 9, 10-dimethyl-1, 2-benzanthracene alone or with croton oil.

Tumors have been induced frequently in the laboratory mouse following exposure to the carcinogenic hydrocarbons (6). In many of these studies, the chemicals were applied continuously and at a relatively high concentration. Cramer and Stowell (5) compared the tumorigenic effectiveness of e0-methylcholanthrene when applied continuously or discontinuously to the skin of mice and concluded that ski...

Induction of Skin Tumors in the Mouse with Minute Doses of 9,10-Dimethyl-l,2-benzanthracene Alone or with Croton Oil*

Tumors have been induced frequently in the laboratory mouse following exposure to the carcinogenic hydrocarbons (6). In many of these studies, the chemicals were applied continuously and at a relatively high concentration. Cramer and Stowell (5) compared the tumorigenic effectiveness of e0-methylcholanthrene when applied continuously or discontinuously to the skin of mice and concluded that ski...

The Binding of 9,10-Dimethyl-l,2-benzanthracene to Mouse Epidermal Satellite DNA in Vivo

We measured the relative binding of the labeled carcinogen 9,10-dimethyl-l,2-benzanthracene-3H (DMBA-3H) to mouse satellite and main-band epidermal DNA 24 hr after the topical application of the carcinogen to mouse skin. Labeled DMBA-bound DNA was fractionated into satellite and main-band components by composite gel electrophoresis and by isopycnic CsCl centrifugation. With both fractionation m...